PI3K inhibitor - Autophagy Inhibitor

Wortmannin is a cell-permeable, fungal metabolite that acts as a potent, selective and irreversible inhibitor of phosphatidylinositol 3-kinase (PI3K) [1].
There is increasing evidence of the involvement of PI3K in Toll-like receptor (TLR) signaling [2]. Inhibition of PI3K with wortmannin enhances TLR-mediated inducible nitric-oxide synthase (iNOS) expression, activates NF-κB and up-regulates cytokine mRNA production [3].
Furthermore, PI3K is required for autophagy [4]. Autophagy is a complex pathway in which cell material can be sequestered and delivered to the lysosome for degradation. Inhibition of PI3K with wortmannin can inhibit autophagic sequestration [4].


Working concentration: 0.1-10 μM
Purity: >95% (LC)
Solubility: 10 mg/ml in DMSO
CAS number:
KY 12420
Molecular weight:


 • 5 mg Wortmannin


1. Arcaro A. & Wymann MP., 1993. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296:297-301.
2. Fukao T & Koyasu S., 2003. PI3K and negative regulation of TLR signaling. Trends Immunol 24: 358-363.
3. Hazeki K. et al, 2006. Opposite Effects of Wortmannin and 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one Hydrochloride on Toll- Like Receptor-Mediated Nitric Oxide Production: Negative Regulation of Nuclear Factor- {kappa}B by Phosphoinositide 3-Kinase. Mol. Pharmacol., 69: 1717 - 1724.
4. Blommaart EF. et al., 1997. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243: 240–246.


Recent articles using InvivoGen Wortmannin



Description PI3K inhibitor
Cat. Codetlrl-wtm
Unit Size5 mg
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