NF-κB inhibitor

Triptolide, a diterpenoid isolated from Tripterygium wilfordii hook F, has been used for centuries in traditional Chinese medicine to treat immune-related disorders. In addition to its anti-inflammatory and immunosuppressive activities, triptolide possesses potent antitumor properties. In a broad range of human tumor cells, Triptolide suppresses cell proliferation and induces apoptosis through caspase activation [1]. At a molecular level, Triptolide inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) [2], and by inhibiting the ATPase activity of XPB [3], a subunit of the general transcription factor TFIIH.  Triptolide interferes with a number of transcription factors including p53 [4], NF-κB [5], nuclear factor of activated T-cells (NFAT) [5] and heat shock factor protein 1 (HSF-1) [6].


Working concentration: 10 - 100 nM
CAS number:
Molecular weight: 360.4
Solubility: DMSO, ethanol (10 mg/ml)


• 1 mg triptolide (white solid)


1. Carter BZ. et al., 2006. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 108: 630 - 637.
2. Wang Y. et al., 2011. Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II). PLoS One. 6(9):e23993.
3. Titov D. et al., 2011. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 7(3):182-8.
4. Chang, W.T. et al., 2001. Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway. J. Biol. Chem. 276, 2221–2227.
5. Qiu D. et al., 1999. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 274, 13443–13450.
6. Westerheide SD. et al., 2006. Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death. J. Biol. Chem., 281: 9616 - 9622.


Recent articles using InvivoGen Triptolide



Description NF-κB Inhibitor
Cat. Codeant-tpl
Unit Size1 mg
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