Trichostatin A

Histone deacetylase Inhibitor

Trichostatin A (TSA), an antifungal antibiotic produced by Streptomyces hygroscopicus [1], is a potent and specific inhibitor of histone deacetylases (HDACs), which are overexpressed in various cancers and closely correlate with oncogenic factors.

Trichostatin A is active at nanomolar concentrations in mammalian cells. By suppressing the activity of HDACs, it leads to increased histone acetylation, thereby causing highly acetylated histones to accumulate in the cell [2]. This in turn induces enhanced expression of specific genes that elicit extensive cellular morphologic and metabolic changes such as growth arrest, differentiation and apoptosis. At submicromolar concentrations Trichostatin A has been shown to induce apoptosis in diverse cancer cells while exhibiting very low toxicity to normal cells.

Interestingly, HDACs epigenetically silence transcription of the autophagy-related genes Atg and LC3. Thus, HDAC inhibitors like Trichostatin A and SAHA can lead to augmented levels of Atg and LC3 proteins and consequently, promote autophagy.


CAS number: 58880-19-6
Formula: C17H22N2O3
Molecular weight: 302.37
Solubility: DMSO (2 mg/ml)


• 1 mg or 5 mg


1. Tsuji N. et al., 1976. A new antifungal antibiotic, trichostatin. J Antibiot (Tokyo). 29(1):1-6.
2. Yoshida M. et al., 1990. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem. 265(28):17174-9.


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Trichostatin A

Description Histone deacetylase inhibitor
Cat. Codemet-tsa-1
Unit Size1 mg
Price For price or distributor address,
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Trichostatin A

Description Histone deacetylase inhibitor
Cat. Codemet-tsa-5
Unit Size5 mg
Price For price or distributor address,
please select your country
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