TLR Antagonists

Toll-Like Receptors (TLRs) share common structures and signaling that leads to NF-κB activation. However, recent data suggest that NF-κB activation may not be uniform and that distinct TLR-ligand associations may trigger multiple pathways.

InvivoGen provides a number of tools that should prove useful to help elucidate the molecular mechanisms involved in TLR signaling. Some TLR ligands bind to the TLRs but unlike agonists they block the signaling cascade, such molecules are known for TLR4 and TLR9.  InvivoGen has also developed neutralizing antibodies against extracellular TLRs.

LPS-RSTLR4 Antagonist - Lipopolysaccharide from R. sphaeroides 5 mg
Ultrapure (1 mg)
ODN 2088TLR9 Antagonist - Inhibitory ODN, preference towards mouse 200 µg
1 mg
5 mg
ODN 2088 controlTLR9 Antagonist - Negative control for ODN 2088 200 µg
1 mg
5 mg
ODN TTAGGG (A151)TLR9 Antagonist - Inhibitory ODN, preference towards human 200 µg
1 mg
ODN TTAGGG controlTLR9 Antagonist - Negative control for ODN TTAGGG 200 µg
1 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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