THP-1 monocytes

Engineered Human Reporter Monocytes

THP1 reporter cells are derived from THP-1, a human monocytic cell line that naturally expresses many pattern-recognition receptors, including Toll-like receptors.

InvivoGen offers several engineered THP-1 cell lines:
THP1-XBlue™ cells stably express an NF-κB/AP-1-inducible reporter (SEAP) system to facilitate the monitoring of TLR-induced NF-κB/AP-1 activation.
THP1 NF-κB cells were specifically designed for monitoring the NF-κB signal transduction pathway in a physiologically relevant cell line. They feature either the SEAP or the secreted luciferase (Lucia) reporter gene.

Both reporter proteins are readily measurable in the cell culture supernatant when using QUANTI-Blue™, a SEAP detection reagent, or QUANTI-Luc™, a luciferase detection reagent

NF-κB/AP-1 Reporter Monocytes

THP1-XBlue™ CellsHuman THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter3-7 x 10e6 cells
THP1-XBlue™-CD14 CellsHuman THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter - CD14 transfected3-7 x 10e6 cells
THP1-XBlue™-MD2-CD14 CellsHuman THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter - MD2 CD14 co-transfected3-7 x 10e6 cells

NF-κB Reporter Monocytes

THP1-Blue™ NF-κB CellsHuman THP-1 Monocytes - NF-kB SEAP Reporter3-7 x 10e6 cells
THP1-Lucia™ NF-κB CellsHuman THP-1 Monocytes - NF-κB Luc Reporter Monocytes3-7 x 10e6 cells
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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