THP1-XBlue™ cells

THP1-XBlue™ cells

NF-κB/AP-1 Reporter Monocytes

THP1-XBlue™ cells are derived from THP-1, a human monocytic cell line that naturally expresses many pattern-recognition receptors, including Toll-like receptors. They stably express an NF-κB/AP-1-inducible SEAP (secreted embryonic alkaline phosphatase) reporter system to facilitate the monitoring of TLR-induced NF-κB/AP-1 activation.

Four cell lines are available: THP1-XBlue™, THP1-XBlue™-CD14, which overexpresses the cell surface protein CD14 for enhanced sensitivity, THP1-XBlue™-MD2-CD14, which overexpresses MD2 and CD14 to increase the response toTLR ligands and THP1-XBlue™-defMyD characterized by a deficient MyD88 activity.

 

THP1-XBlue™ cells Products

THP1-XBlue™ cells NF-kB/AP-1 Reporter Monocytes 5-7 x 10e6 cells
THP1-XBlue™-CD14 cells NF-kB/AP-1 Reporter CD14 transfected Monocytes 5-7 x 10e6 cells
THP1-XBlue™-MD2-CD14 cells NF-kB/AP-1 Reporter MD2 CD14 co-transfected Monocytes 5-7 x 10e6 cells
THP1-XBlue™-defMyD cells NF-kB/AP-1 Reporter MyD88-deficient Monocytes 5-7 x 10e6 cells
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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