THP-1 monocytes

Engineered Human Reporter Monocytes

THP1 reporter cells are derived from THP-1, a human monocytic cell line that naturally expresses many pattern-recognition receptors, including Toll-like receptors.

InvivoGen offers several engineered THP-1 cell lines:
THP1-XBlue™ cells stably express an NF-κB/AP-1-inducible reporter (SEAP) system to facilitate the monitoring of TLR-induced NF-κB/AP-1 activation.
THP1 NF-κB cells were specifically designed for monitoring the NF-κB signal transduction pathway in a physiologically relevant cell line. They feature either the SEAP or the secreted luciferase (Lucia) reporter gene.

Both reporter proteins are readily measurable in the cell culture supernatant when using QUANTI-Blue™, a SEAP detection reagent, or QUANTI-Luc™, a luciferase detection reagent

THP-1 monocytes

NF-κB/AP-1 Reporter Monocytes

THP1-XBlue™ Cells Human THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter 3-7 x 10e6 cells
THP1-XBlue™-CD14 Cells Human THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter - CD14 transfected 3-7 x 10e6 cells
THP1-XBlue™-MD2-CD14 Cells Human THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter - MD2 CD14 co-transfected 3-7 x 10e6 cells
THP1-XBlue™-defMyD Cells Human THP-1 Monocytes - NF-kB/AP-1 SEAP Reporter - MyD88-deficient 3-7 x 10e6 cells

NF-κB Reporter Monocytes

THP1-Blue™ NF-κB Cells Human THP-1 Monocytes - NF-kB SEAP Reporter 3-7 x 10e6 cells
THP1-Lucia™ NF-κB Cells Human THP-1 Monocytes - NF-κB Luc Reporter Monocytes 3-7 x 10e6 cells
Disclaimer: Our products are provided for research purposes only. Not for use in humans. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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