SSL7 / Agarose
SSL7 (Staphylococcus aureus superantigen-like protein 7; formally known as SET1), is a staphylococcus toxin isolated from Staphylococcus aureus. SSL7 binds with a high affinity to the monomeric form of human IgA1 and IgA2.
SSL7 has no affinity for human IgG, therefore, it can be used to purify human IgA from human sera, milk and other biological samples [1,2].
SSL7 also binds the secretory form of IgA found in milk from humans, cows, and sheep. SSL7 will bind bovine IgA antibodies present in milk, but not bovine IgA present in serum. SSL7 does not bind mouse, rabbit, sheep or goat IgA present in serum [1].
Specifications
Binding capacity: 0.6 - 1 mg human IgA per ml of gel
Documents
Contents
SSL7 / Agarose is available in two quantities:
• gel-ssl-2: 2 ml SSL7 / Agarose provided as a 50% v/v gel slurry in PBS 20% v/v ethanol (total volume 4 ml)
• gel-ssl-10: 10 ml SSL7 / Agarose provided as a 50% v/v gel slurry in PBS 20% v/v ethanol (total volume 20 ml)
Ref.
1. Langley et al., 2005. The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria. J Immunol 174 :2926-2933.
2. Ramsland PA. et al., 2007. Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1. PNAS 104:15051-15056.
ORDERING
SSL7 / Agarose
| Cat. Code | gel-ssl-2 |
|---|---|
| Unit Size | 2 ml |
| Price | For price or distributor address, please select your country |
SSL7 / Agarose
| Cat. Code | gel-ssl-10 |
|---|---|
| Unit Size | 10 ml |
| Price | For price or distributor address, please select your country |
