Our Products
- Native Genes
- TLR Genes
- TLR Co-receptor Genes
- Adaptor Genes
- TLR Regulator Genes
- Signaling Genes
- Signaling Inhibitors
- Transcription Factors
- RLR Genes
- NLR Genes
- CLR, PGRP & Related Genes
- Modified Genes
- TLR Vectors
TLR & TLR Related Genes
Toll-Like Receptors interact with co-receptor molecules to recognize specific molecular patterns associated with microbial pathogens.
Upon recognition, they induce distinct cellular responses that involve different adaptor proteins which in turn will activate a cascade of signaling genes leading to the production of proinflammatory cytokines.
InvivoGen offers a large selection of human and mouse genes involved in the TLR pathways.
TLR and TLR-related genes are provided either native, cloned from the ATG to the Stop codon, or modified by addition of a tag and/or deletion to generate dominant negative variants.
Native Genes
• Toll-like receptor genes
• TLR co-receptor genes
• TLR adaptor genes
• TLR regulator genes
• Signaling genes
• Signaling inhibitors
• Transcription factors
• RLR genes
• NLR genes
• CLR, PGRP & Related genes
Native TLR and TLR-related genes are provided in the pUNO plasmid that can be amplified in E.coli and stably transfected in mammalian cells using blasticidin.
Modified Genes
• HA-tagged genes
HA-tagged genes are provided in the pUNO-HA plasmid, selectable with blasticidin.
• Dominant negative (DN) variants
Dominant negative variants are provided in either in the pZERO-TLR or pDeNy plasmids selectable with puromycin or Zeocin™ respectively.
• HA-tagged DN genes
HA-tagged dominant negative genes are provided in the pZERO-TLR-HA plasmid selectable with puromycin.
• TLR-GFP fusion genes
TLR-GFP fusion genes are provided in the pUNO-TLR-GFP plasmid selectable with blasticidin.