Our Products
- siRNA Wizard™ Software
- siRNA/shRNA Insert Cloning
- siRNA/shRNA Prevalidation
- Silencing Efficiencies
psiRNA™ System
InvivoGen provides a plasmid-based system developed to knockdown efficiently the expression of a wide variety of mammalian genes. This system represents a simple and affordable method to generate short hairpin RNAs (shRNAs) by eliminating the need to synthesize RNA oligonucleotides.
The psiRNA System is designed to assist you in all the steps necessary to obtain efficient silencing of a gene of interest from the selection of an effective siRNA/shRNA to its prevalidation.
Selection of Candidate siRNA/shRNA and Design of Hairpin Insert: siRNA Wizard Software
Based on the research from various laboratories including our own, InvivoGen has been able to develop siRNAWizard, a free software accessible online, that will help you to select effective and specific candidate siRNA/shRNA, design hairpin insert and generate siRNA/shRNA scramble sequence.
InvivoGen provides psiRNA-h7SK and psiRNA-DUO, a family of cloning vectors featuring the human 7SK RNA polymerase III promoter and a choice of selection markers.
These plasmids are provided in a kit that contains, in addition to the cloning vector, two control vectors, and a set of tools : psiRNA™ Tools.
Prevalidation of siRNA/shRNA: psiTEST System
The psiTEST System was developed to provide a rapid, simple, and convenient method to screen for functional siRNA and shRNA sequences. The silencing efficiency of a given siRNA or shRNA is evaluated by monitoring the reduction of expression of a chimeric gene consisting of a secreted alkaline phosphatase (SEAP) reporter gene transcriptionally fused to the target gene.