MAP Kinase Inhibitor - Autophagy Inhibitor - JNK inhibitor

SP600125 is a potent, cell-permeable, selective and reversible inhibitor of c-Jun N-terminal kinase (JNK) [1].

It inhibits in a dose-dependent manner the phosphorylation of JNK. JNK is a member of the mitogen-activated protein kinase (MAPK) family and plays an essential role in TLR mediated inflammatory responses [2, 3].

Inhibition of JNK activity by SP600125 is usually associated with downregulation of Beclin-1 and reduced autophagy.


Working concentration: 10-50 µM
CAS number:
SAPK inhibitor II
Molecular weight: 220.2
100 mM in DMSO and 10 mM in ethanol
>99% (HPLC)


• 10 mg


1. Bennett Bl. et al., 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.Proc. Natl. Acad. Sci. USA. 98:13681-13686.
2. Kenzel S. 2006. c-Jun Kinase Is a Critical Signaling Molecule in a Neonatal Model of Group B Streptococcal Sepsis1. J Immunol. 176:3181-3188.
3. Adhikary G. et al., 2008. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J. Leukoc. Biol., 83: 991-997.


Recent articles using InvivoGen SP600125



Description JNK inhibitor
Cat. Codetlrl-sp60
Unit Size10 mg
Price For price or distributor address,
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