Soluble PRR Receptors

Soluble Receptor:Fc Fusion ProteinsInvivoGen provides soluble forms of the pattern recognition receptors, Dectin-1 and TLR5, that consist of the extracellular domain (ECD) of each receptor fused to an IgG1 Fc domain, engineered to reduce ADCC and enhance half-life.

Dectin-1, which is a type-II transmembrane receptor, is fused to the C-terminus of the Fc domain while TLR5, which is a type-1 transmembrane receptor is fused to the N-terminus of the Fc domain.
The Fc fusion proteins are expressed in CHO cells and purified by protein G affinity chromatography.

The soluble Dectin-1 and TLR5 receptors can be used for receptor binding assays or neutralization studies.

Soluble Dectin-1 Receptor

Fc-hDectin-1aSoluble human Dectin-1 receptor50 µg
Fc-mDectin-1aSoluble murine Dectin-1 receptor50 µg

Soluble TLR5 Receptor

hTLR5-FcSoluble ectodomain of human TLR5 - TLR5 inhibitor50 µg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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