SC79 is a selective and cell-permeable activator of Akt (also known as protein kinase B), a serine/threonine protein kinase signaling molecule with anti-apoptotic activity [1, 2]. The Akt kinase family comprises three highly homologous isoforms: Akt1 (PKBα), Akt2 (PKBβ) and Akt3 (PKBγ). SC79 potently activates all three isoforms and functions effectively in multiple cells types, including HeLa and HEK293 cells [2]. Interestingly, in animal models SC79 exhibits protective effects against the apoptotic and oxidative damage caused by ultraviolet radiation [1]. Moreover, this bloodbrain barrier permeable molecule displays neuroprotective properties in experimental stroke models possibly through its dual antiapoptotic and antioxidative activities [2, 3].


Purity: ≥95% (UHPLC)
Solubility: 10 mg/ml (27.26 mM) in DMSO
CAS: 305834-79-1
Molecular weight: 366.8 g/mol
Formula: C17H19ClN2O5

Quality control: The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells. The inhibitory activity of the product has been validated using cellular assays.


• 10 mg


Structure of SC79


  1. Gong YQ. et al., 2016. SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling. Oncotarget. 7(37):60123-60132.
  2. Jo H. et al., 2012. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. PNAS 109(26):10581-6.
  3. Zhang D. et al., 2016. Akt Specific Activator SC79 Protects against Early Brain Injury following Subarachnoid Hemorrhage. ACS Chem Neurosci. 2016;7:710–8.



Description Akt activator; autophagy inhibitor
Cat. Codeinh-sc79
Unit Size10 mg
Price For price or distributor address,
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