Reprogramming Enhancer - TGF-β receptor inhibitor

SB431542 is a potent and selective inhibitor of transforming growth factor-β (TGF-β) superfamily type I activin receptor-like kinase (ALK) receptors, specifically ALK4, ALK5 and ALK7 [1]. Inhibition of TGF-β signaling is known to induce the de-repression of epithelial fate and thus was hypothesized to benefit the reprogramming process. Indeed, treatment of OSKM-transduced human primary fibroblasts with a combination of SB431542 and PD0325901, a MEK inhibitor, was found to improve reprogramming efficiency of human cells [2].


Working concentration: 2 µM
Purity: >99% (HPLC)
CAS number: 301836-41-9
Molecular weight:
approx. 20 mg/ml in DMSO or DMF. Approx. 2 mg/ml in ethanol


• 5 mg SB431542


1. Inman GJ. et al., 2002. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002 Jul;62(1):65-74.
2. Lin T. et al., 2009. A chemical platform for improved induction of human iPSCs. Nat Methods. 6(11):805-8.


Recent articles using InvivoGen SB431542



Description TGF-β receptor inhibitor
Cat. Codeinh-sb43
Unit Size5 mg
Price For price or distributor address,
please select your country
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "".