Pan-Histone deacetylase Inhibitor

SAHA, suberoylanilide hydroxamine, also known as Vorinostat, is a pan-Histone deacetylase inhibitor.
SAHA binds to the active site of histone deacetylases and act as a chelator for Zinc ions also found in the active site of histone deacetylases. SAHA has been in clinical development as a anti-cancer drug, and has antifibrotic and anti-inflammatory potential [1,2].
The antitumor activity of SAHA has been demonstrated both in vitro and in vivo with little or no toxicity to normal cells. Under its trade name Vorinostat, SAHA has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced cutaneous T-cell-lymphoma [3].

Since Histone deacetylases epigenetically silence the transcription of Atg and LC3 genes. Thus, Histone deacetylase inhibitors, as SAHA and Trichostatin A  can lead to an increase of Atg and LC3 proteins levels and promote autophagy.


Synonym: Vorinostat
CAS number: 149647-78-9
Formula: C14H20N2O3
Molecular weight: 264.32
Solubility: 66 mg/ml in DMSO
Purity: >97% (UHPLC)
Working concentration: 0.1 - 10 µM


- 25 mg SAHA

SAHA is provided as a solid and shipped at room temperature.
Store at -20°C. Solid product is stable 2 years when properly stored.


1. Bolden JE. et al., 2006. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5(9):769-784.
2. Wang Z. et al., 2009. Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis? EurRespir J. 34(1):145-155.
3. Mann BS. et al., 2006. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 12: 1247–1252.



Description Pan-Histone deacetylase Inhibitor
Cat. Codeinh-saha
Unit Size25 mg
Price For price or distributor address,
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