pp242 (also known as Torkinib) is a potent, selective and ATP‑competitive inhibitor of mTOR (mammalian target of rapamycin) kinase, a key protein kinase of the PI3K/AKT signaling pathway that plays a central role in controlling cell growth, proliferation, and survival. mTOR is a major negative regulatory axis of autophagy. Thus, pp242 is an effective inducer of autophagy [1]. Specifically, pp242 is able to induce autophagy by inhibiting the two mTOR-containing complexes (mTORC1 and mTORC2), neither of which is fully blocked by classical mTOR inhibitors such as rapamycin [2-4].


Working concentration: 50-400 nM (Fibroblasts and solid tumor cell lines) , 1 µM (MEF).
   cf TDS.
Purity: >97% (HPLC)
Solubility: 62 mg/ml (201.1 mM) in DMSO. 18 mg/ml (58.4 mM) in ethanol.
CAS number: 1092351-67-1
Formula: C16H16N6O
Molecular weight: 308.3
Quality control: The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.


• 5 mg of pp242

pp242 is provided lyophilized and shipped at room temperature. Store at -20 °C. Lyophilized pp242 is stable for 2 years when properly stored. Upon resuspension, prepare aliquots of pp242 and store at -20 °C. Resuspended pp242 is stable for 6 months when properly stored.


  1. Zhou J. et al., 2013. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 23(4):508-23. 
  2. Feldman, ME. et al., 2009. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7:371-83.
  3. Shao H. et al., 2009. Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo. J. Hepatol. 56(1):176-83. 
  4. Janes MR. et al., 2010. Effective and selective targeting of Ph+ leukemia cells using a TORC1/2 kinase inhibitor. Nat Med. 16(2):205-213.



Description mTOR inhibitor
Cat. Codeinh-pp242
Unit Size5 mg
Price For price or distributor address,
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