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pFUSE-hIgG1e9-Fc

Product Unit size Cat. code Docs. Qty. Price

pFUSE-hIgG1e9-Fc1

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20 µg

pfc1-hg1e9
+-
$684

pFUSE-hIgG1e9-Fc2

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20 µg

pfc2-hg1e9
+-
$684

pFUSE-hIgG1e9-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/I332E/G236A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.

pFUSE-hIgG1e9-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.

Richards JO,. et al., 2008. Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells. Mol Cancer Ther. 7(8):2517-27.

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Specifications

Isotype: IgG1 human
Mutations: S239D/I332E/G236A
Characteristics:
- Increased FcγRIIa/FcγRIIb ratio
- Increased macrophage phagocytosis

Both plasmids are selectable with Zeocin™.

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pFUSE Contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin® (100 mg/ml)

room temperature Product is shipped at room temperature

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