Akt inhibitor - Autophagy inducer

Perifosine is an alkylphospholipid exhibiting antitumor activity. It induces cell cycle arrest and apoptosis through the inhibition of the serine-threonine protein kinase Akt (also known as protein kinase B) [1]. In addition, perifosine inhibits mTOR signaling through a different mechanism than classical mTOR inhibitors such as rapamycin [2].

Perifosine is the best characterized inhibitor of Akt. mTOR is a target for Akt, the activation of which suppresses autophagy. Therefore, treatment with perifosine, alone or in combination with rapamycin, induces autophagy.


Synonym: KRX-0401
CAS number:
Molecular weight:
50 mg/ml in water with warming
   - 200 mg/ml in ethanol
>99% (NMR)
Working concentration:
5 - 50 µM


- 5 mg Perifosine

Perifosine is provided as a solid and shipped at room temperature. Store at -20°C.
Solid product is stable 2 years at -20°C.


1. HideshimaT. et al., 2006. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood. 107(10):4053-62.
2. Sun SY., 2010. Enhancing perifosine's anticancer efficacy by preventing autophagy. Autophagy. 6(1):184-5.



Description Akt inhibitor
Cat. Codetlrl-peri
Unit Size5 mg
Price For price or distributor address,
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