Th2 response

pBOOST2-wtIRF1 plasmids express the human or murine wild-type interferon regulatory factor 1 (IRF-1) gene. IRF-1 has been described to primarily increase Th2 antibody responses [1]. Following intramuscular or gene gun injections of DNA vaccines, IRF-1 can increase the titers of antibodies up to 10-fold.

pBOOST2-wtIRF1 plasmids express the transgene under the control of the strong and ubiquitous EF-1α/HTLV composite promoter and are selectable in E. coli with Zeocin™.


Gene: wild-type IRF-1 gene
Human or Murine
Selection: Zeocin

Th2 polarization


- 20 µg of lyophilized DNA
- 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)

Product is shipped at room temperature. Store at -20°C. Plasmids are stable up to one year when properly stored.


pBOOST2 map


1. Sasaki S. et al., 2002. Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors. J Virol.76(13):6652-9.



Description pBOOST2 Human Wild-type IRF-1
Cat. Codepbst2-wthirf1
Unit Size20 µg
Price For price or distributor address,
please select your country


Description pBOOST2 Murine Wild-type IRF-1
Cat. Codepbst2-wtmirf1
Unit Size20 µg
Price For price or distributor address,
please select your country
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