DNA Vaccine Adjuvants

pBOOST plasmids were developed as genetic adjuvants for DNA vaccines to potentiate the immune response to a specific antigen. The method of plasmid DNA vaccine delivery is known to bias the immune response to a specific antigen towards a Th1 or Th2 response. These biases can be further enhanced by the codelivery of interferon regulatory factors (IRFs) or TANK-binding kinase 1 (TBK1) to increase the efficacy of the vaccination.

• pBOOST2 plasmids feature different IRFs for Th1 or Th2 polarization.

• pBOOST3 plasmid features TBK1 to enhance DNA vaccine immunogenicity.

pBOOST2 wtIRF1Genetic adjuvants for DNA vaccines with wild-type IRF1 genes
Increase Th2 response
Human Wild-type IRF-1 (20 µg)
Mouse Wild-type IRF-1 (20 µg)
pBOOST2 saIRF-3Genetic adjuvants for DNA vaccines with mutant IRF-3 gene
Increase Th1 response
Human Mutant IRF-3 (20 µg)
Mouse Mutant IRF-3 (20 µg)
pBOOST2 saIRF7/3Genetic adjuvants for DNA vaccines with chimeric IRF-7/IRF-3 gene
Increase both Th1 T-cell and Th2 responses
Human Chimeric IRF7/3 (20 µg)
Mouse Chimeric IRF7/3 (20 µg)
pBOOST3 mTBK1Genetic adjuvants for DNA vaccines with murine TBK1TBK1 (20 µg)
pBOOST ControlNegative control for genetic adjuvants pBOOST plasmids pBOOST3 MCS (20 µg)
pBOOST2 MCS (20 µg)
pBOOST2 LacZ (20 µg)
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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