ORN Sa19

ORN Sa19 is a 19 mer S. aureus 23S rRNA derived oligoribonucleotide, ORN Sa19, which contains an A in its center to mirror S. aureus A2085, is highly stimulatory in TLR13-expressing cells in contrast to ORN Sa19 Control, which carries a G in place of the central A.


Specificity: murine TLR13 agonist

Working concentration: 0.02-2 μg/ml

ORN Sa19 sequence
ORN Sa19 is a 19 mer S. aureus 23S rRNA derived oligoribonucleotide, stabilized by phosphorothioate modification.


- 200 μg lyophilized ORN Sa19
- 2 ml endotoxin-free water

ORN Sa19 is provided lyophilized and shipped at room temperature. Store at -20°C.


Toll-like receptor 13 is an endosomal murine TLR which role and ligand remain unclear.
Three independent teams have identified bacterial single-stranded RNA as a TLR13 ligand [1, 2, 3].
More precisely, a conserved 23S ribosomal RNA (rRNA) sequence, “CGGAAAGACC”, was shown to induce cytokine production in a TLR13-, MyD88 and UNC93B-dependent manner. Interestingly, this rRNA sequence is the binding site of the macrolide-lincosamide-streptogramin (MLS) group of antibiotics, and 23S rRNA from bacteria resistant to these antibiotics is not recognized by TLR13 [1].
Further, these data reveal a mechanism developed by bacteria to evade host innate immune system through acquisition of antibiotic resistance.

1. Oldenburg M. et al., 2012. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science. 337(6098).
2. Hidmark A. et al., 2012. Cutting edge: TLR13 is a receptor for bacterial RNA. J Immunol. 189(6):2717-21.
3. Li XD & Chen ZJ. 2012. Sequence specific detection of bacterial 23S ribosomal RNA by TLR13. elife. 1:e00102.


Recent articles using InvivoGen ORN Sa19


ORN Sa19

Description TLR13 Agonist - 23S rRNA derived oligoribonucleotide
Cat. Codetlrl-orn19
Unit Size200 µg
Price For price or distributor address,
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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