InvivoGen Insight Newsletters


The RIG-I and STING Alliance

The innate immune system is crucial to limit viral infections. It relies on several groups of pattern recognition receptors (PRRs) that recognize viral nucleic acids1. These PRRs include the cytosolic DNA sensor (CDS), cyclic GMP-AMP synthase (cGAS), and the cytoplasmic RNA sensor, retinoic acid inducible gene I (RIG-I). Once activated, they induce different signaling pathways leading to the production of a variety of antiviral molecules. Interestingly, evidence suggests that these signaling pathways are tightly interconnected to potentiate the antiviral more

  Previous Issues

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  • Spring 2017 - Mitochondrial DNA in innate immunity and autophagy
  • Winter 2015/16 - Improving the efficacy of clinical antibodies
  • Winter 2014/15 - Inflammasome activation: a matter of caspases
  • Winter 2013/14 - Deciphering the STING Paradox
  • Fall 2013 - β-Glucans: bittersweet ligands of Dectin-1
  • Spring 2013 - Multi-TLR Agonists: Potential for Therapeutic Success
  • Fall 2012 - Cytosolic DNA Sensors (CDSs): a STING in the tail
  • Summer 2012 - Lucia™, a novel secreted luciferase
  • Winter 2011 - Mycoplasma Detection and Elimination
  • Summer 2011 - Antibody and Vaccine adjuvants
  • Fall 2010 - Cytosolic dsDNA Sensors (CDS)
  • November 2009 - NLRP3 Inflammasome
  • Sept/Oct 2008 - DAMPs & DAMP Receptors
  • June/July 2008 - Vaccine Adjuvants
  • January 2008 - Immunoglobulin A
  • October 2007 - TLR9 Ligands
  • May 2007 - Toll-Like Receptor 4
  • December 2006 - RNA Interference
  • September 2006 - TLR7 and TLR8
  • May 2006 - Fc Fusion: pFUSE-Fc
  • November 2005 - Mycoplasma
  • September 2005 - TLR Signaling and IRF Activation Pathways
  • June 2005 - TLR Ligands

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