mTOR & Calcineurin Signaling Inhibitors

Mammalian target of rapamycin (mTOR), a serine/threonine kinase also known as FKBP12-rapamycin-associated protein (FRAP), is a master regulator of protein biosynthesis, cell growth and autophagy. mTOR is implicated in many disease states and is a target for the design of anticancer agents.
Calcineurin signaling is involved in the activation of T cells. Calcineurin is a Ca2+ and calmodulin dependent serine/threonine phosphatase that activates the NFAT transcription factor, which stimulates the T cell response through IL-2 expression.
InvivoGen provides inhibitors that block mTOR activation and signaling by Calcineurin.

Pathways of inhibition of mTOR and calcineurin activation

3-MethyladeninePI3K inhibitor - Autophagy Inhibitor50 mg
A-769662AMPK Activator (mTOR Inhibitor)10 mg
BEZ235 NEWPI3K/mTOR inhibitor50 mg
Cyclosporin ACalcineurin inhibitor100 mg
EverolimusmTOR inhibitor - Autophagy Inducer5 mg
FK506Calcineurin inhibitor10 mg
LY294002PI3K inhibitor - Autophagy Inhibitor5 mg
MetforminAMPK activator - Autophagy inducer1 g
OSU-03012PDK1 Inhibitor10 mg
PerifosineAkt inhibitor - Autophagy inducer5 mg
PI-103PI3K/mTOR inhibitor5 mg
pp242 NEWmTOR inhibitor5 mg
RapamycinmTOR inhibitor - TLR signaling inhibitor - Autophagy Inducer5 mg
SB203580MAP Kinase Inhibitor - p38 MAP Kinase Inhibitor - Autophagy inducer5 mg
SB216763GSK3 Inhibitor5 mg
TamoxifenEstrogen receptor antagonist - Autophagy inducer200 mg
TemsirolimusmTOR inhibitor10 mg
Torin 1 NEWmTOR inhibitor10 mg
WortmanninPI3K inhibitor - Autophagy Inhibitor5 mg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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