PI3K inhibitor - Autophagy Inhibitor

LY294002 is a potent, cell permeable inhibitor of phosphatidylinositol 3-kinase (PI3K) that acts on the ATP binding site of the enzyme [1].
The PI3K pathway is extensively studied for its role in inhibiting apoptosis. PI3K is also known to regulate TLR-mediated inflammatory responses [2, 3].
Furthermore, PI3K is required for autophagy [4]. Autophagy is a complex pathway in which cell material can be sequestered and delivered to the lysosome for degradation. Inhibition of PI3K with LY294002 can inhibit autophagic sequestration [4].


Working concentration: 1 -100 μM
Purity: ≥99% 
Solubility: DMSO (10 mg/ml)
CAS number: 
Molecular weight:


 • 5 mg LY294002


1. Vlahos CJ. et al., 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem 69(7):5241-8.
2. Kuo CC. et al., 2006. Class I and III Phosphatidylinositol 3'-Kinase Play Distinct Roles in TLR Signaling Pathway. J. Immunol., 176: 5943 - 5949.
3. Guiducci C. et al., 2008. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J. Exp. Med., 205: 315 - 322.
4. Blommaart EF. et al., 1997. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243: 240–246.


Recent articles using InvivoGen LY294002



Description PI3K Inhibitor
Cat. Codetlrl-ly29
Unit Size5 mg
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