JAK/STAT Activation Inhibitors

The JAK/STAT pathway plays an important role in cytokine receptor-mediated signal transduction via activation of downstream signal transducers and activators of transcription (STAT), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) pathways.
These inhibitors are useful tools for exploring the contribution of JAK/STAT-mediated signaling.

Pathways of inhibition of JAK/STAT activation

AG490JAK2 inhibitor10 mg
AZD1480JAK1 & JAK2 inhibitor5 mg
CP-690550JAK3 Inhibitor5 mg
CYT387JAK1/JAK2 & TBK1/IKK-ε inhibitor10 mg
RuxolitinibJAK1 & JAK2 Inhibitor5 mg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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