A162 isoform human STING (S162A) coding sequence in expression plasmid

STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs).
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.

Human wild-type STING fails to bind DMXAA, a potent tumor vascular disrupting agent in mice [1]. The allele A162 contains a unique point mutation (S162A) placed at the cyclic-dinucleotide-binding site which confers DMXAA sensitivity to hSTING [2].

This gene is available in pUNO1 expression plasmid selectable with Blasticidin.


Human STING-A162 (pUNO1-hSTING-A162)

   ORF Size: 1139 bp
   Subclone: BspEI - NheI


- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml


1. Conlon J. et al., 2013. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol 190(10):5216-25.
2. Gao P. et al., 2013. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 154(4):748-62.



Description pUNO1 bearing the A162 isoform human STING (S162A) gene
Cat. Codepuno1-hsting-a162
Unit Size20 µg
Price For price or distributor address,
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