Heat Shock Protein Inhibitors

Geldanamycin & Analogs

Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone critical for the folding, assembly and activity of multiple mutated and overexpressed signaling proteins that promote the growth and/or survival of tumor cells.
Hsp90 client proteins include mutated p53, Raf-1, Akt, ErbB2 and hypoxia-inducible factor 1a (HIF-1a).

Geldanamycin (GA), a benzoquinone ansamycin antibiotic, selectively inhibits Hsp90 leading to the degradation of its client proteins. GA inhibits the proliferation of cancer cells and shows anti-cancer activity in experimental animals. However due to poor aqueous solubility and liver toxicity, GA has not moved forward in clinical trials. To overcome these undesirable properties, numerous GA analogs have been synthesized which differ only in their 17-substituent. These include 17-allylamino-demethoxygeldamycin (17-AAG) and 17-dimethylamino- geldanamycin (17-DMAG) that have completed phase I and are currently entering phase II clinical trials.

InvivoGen provides Geldanamycin and four of its more promising analogs as well as other derivatives.
Bulk quantity readily available - contact us

Heat Shock Protein Inhibitors

Geldanamycin GA - HSP90 Inhibitor 5 mg
25 mg
17-AAG Geldanamycin Analog - Less Toxic and More Stable 5 mg
25 mg
17-DMAG Geldanamycin Analog - Water-Soluble 5 mg
25 mg
17-AEP-GA Geldanamycin Analog - Water-Soluble 1 mg
5 mg
17-DMAP-GA Geldanamycin Analog - Water-Soluble 1 mg
5 mg

For conjugation

17-GMB-APA-GA Geldanamycin Analog for Conjugation to a Monoclonal Antibody 1 mg
17-NHS-ALA-GA Geldanamycin Analog for Coupling of NH2-Containing Molecules 1 mg

Labeled Geldanamycin

Biotin-Geldanamycin Biotin-labeled Geldanamycin 1 mg
5 mg
FITC-Geldanamycin FITC-labeled geldanamycin 1 mg
5 mg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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