hPD-L1-Fc is a soluble human PD-L1 (CD274) fusion protein generated by fusing the N-terminal extracellular domain of human PD-L1 (aa 19-237) to the N-terminus of an engineered human IgG1 Fc domain with a 2 amino acid linker. hPD-L1-Fc has an apparent molecular weight of ~66 kDa on an SDS‑PAGE gel.

hPD‑L1‑Fc is expressed in CHO cells and purified by protein G affinity chromatography.


Applications: Flow cytometry, protein-protein interaction studies, T cell activation blocking (binding to hPD-1 expressed on T cells).

Formulation: 0.2 µm filtered solution in sodium phosphate buffer with glycine, saccharose and stabilizing agents


- 50 µg lyophilized hPD-L1-Fc.
- 1.5 ml endotoxin-free water.

Product is shipped at room temperature. 
Store lyophilized product at -20°C. Product is stable for at least 1 year.


Programmed cell death ligand 1 (PD-L1), also known as B7 homolog 1 (B7-H1) and cluster of differentiation 274 (CD274), is a member of the B7 family of immunoregulatory proteins [1]. It is a transmembrane protein over‑expressed on tumor cells and tumor infiltrating immune cells, such as macrophages. PD-L1 binds to programmed cell death protein 1 (PD-1; also known as CD279) on cytotoxic T cells, inhibiting the antitumor immune response [2,3].

  1. Collins M. et al., 2005. The B7 family of immune-regulatory ligands. Genome Biol. 6(6):223.
  2. McDermott D. & Atkins M. 2013. PD-1 as a potential target in cancer therapy. Cancer Med. 2(5): 662–673.
  3. Herbst RS. et al., 2014. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 515(7528):563-7.



Description Soluble human PD-L1 fused to an IgG1 Fc domain
Cat. Codefc-hpdl1
Unit Size50 µg
Price For price or distributor address,
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