An inhibitor of the heat-shock protein Hsp 90

Geldanamycin (GA) is a natural product produced by Streptomyces hygroscopicus.

InvivoGen produces GA from a mutant strain of S. hygroscopicus, inactivated for the synthesis of nigericin, a common contaminant of GA.

GA binds with high affinity into the ATP binding pocket of Hsp90. Hsp90 is a ubiquitous molecular chaperone critical for the folding, assembly and activity of multiple mutated and overexpressed signaling proteins that promote the growth and/or survival of tumor cells.
Hsp90 client proteins include mutated p53, Raf-1, Akt, ErbB2 and hypoxia-inducible factor 1a (HIF-1a) [1]. Binding of GA to Hsp90 causes the destabilization and degradation of its client proteins [2].


Working concentration: 1 nM - 10 μM
CAS number: 30562-34-6
Formula: C29H40N2O9
Molecular weight: 560
Solubility: Soluble in DMSO (1 mg/ml)


-  5 mg or 25 mg


1. Neckers L., 2002. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8(4 Suppl):S55-61.
2. Whitesell L. et al., 1994. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. PNAS 91(18):8324-8.


Recent articles using InvivoGen Geldanamycin



Cat. Codeant-gl-5
Unit Size5 mg
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Cat. Codeant-gl-25
Unit Size25 mg
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