Our Products
- TLR Antagonists
- Signal Transduction Inhibitors
- Dominant Negative TLRs
- TLR shRNAs
- TLR-Related shRNAs
TLR Inhibitors
Related Products
Toll-Like Receptors share common structures and signaling that leads to NF-κB activation. However, recent data suggest that NF-κB activation may not be uniform and that distinct TLR-ligand associations may trigger multiple pathways. InvivoGen provides a number of tools that should prove useful to help elucidate the molecular mechanisms involved in TLR signaling.
TLR antagonists
Some TLR ligands bind to the TLRs but unlike agonists they block the signaling cascade. Such molecules are known for TLR9.
Dominant negative TLRs
InvivoGen has engineered TLR genes deleted for the TIR domain (TLR-TIR) that act as dominant negatives. Human and mouse TLR-TIR genes are available in an expression vector called pZERO-TLR.
TLR and TLR-related shRNAs
Using the siRNA Wizard software, InvivoGen has designed and cloned sequences that code for short hairpin RNAs (shRNAs) that functionally silence a number of TLR and TLR-related genes. These shRNAs are available as ready-made psiRNA plasmids.
Inhibitors of TLR signaling
Inhibitors of TLR signaling are molecules that intervene in the different steps of the TLR activation and signaling cascade, including TLR binding, TLR relocalization and MAP kinases and transcription factors activation.
TLR Antagonists
DNA sequences that inhibit the activation of TLR9 by stimulatory CpG ODNs have been identified. The most potent inhibitory sequences are (TTAGGG)4 found in mammalian telomeres and ODN 2088 which derives from a murine stimulatory CpG ODN by replacement of 3 bases. Recently, another suppressive, guanosine-rich ODN, named G-ODN, was described. G-ODN was suppressive in murine DC and macrophages as well as in human plasmacytoid DC.
| Product | Specificity | Endotoxin Level | Working Conc. | TDS | MSDS | Qty | Cat. Code | Price | Order |
|---|---|---|---|---|---|---|---|---|---|
|
ODN 2088
|
Mouse preferred | Endotoxin-free | 50 nM - 1 µM | 200 µg | tlrl-minhodn | check |  | ||
|
ODN 2088 control
|
Endotoxin-free | 50 nM - 1 µM | 200 µg | tlrl-minhodnc | check | | |||
|
ODN TTAGGG
|
Human preferred | Endotoxin-free | 50 nM - 1 µM | 200 µg | tlrl-hinhodn | check | | ||
|
ODN TTAGGG control
|
Endotoxin-free | 50 nM - 1 µM | 200 µg | tlrl-hinhodnc | check | | |||
|
G-ODN
|
Endotoxin-free | 50 nM - 1 µM | 200 µg | tlrl-godn | check | |