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Phleomycin

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Phleomycin

Phleomycin is a glycopeptide antibiotic of the bleomycin family, isolated from a mutant strain of Streptomyces verticillus. It binds and intercalates DNA thus destroying the integrity of the double helix. Phleomycin is active against most bacteria, filamentous fungi, yeast, plant and animal cells.
Use of phleomycin is recommended for cells poorly sensitive to Zeocin™, i.e. filamentous fungi and some yeasts. Phleomycin resistance is conferred by the Sh ble gene from Streptoalloteichus hindustanus which encodes a protein that binds to phleomycin, inhibiting its DNA cleavage activity.

Typically, phleomycin is used at a concentration of 10 µg/ml for yeasts and 25-150 µg/ml for filamentous fungi.

Empirical formula: C₅₅H₈₅O₂₁N₂₀S₂Cu-HCL
Molecular weight: 1525
CAS Number: 11006-33-0

Bulk quantities available at highly discounted prices : Contact info@invivogen.com

Contents and Storage

Phleomycin is provided as a blue solution at 20 mg/ml or as a powder.
Phleomycin is shipped at room temperature. Store the solution at -20°C and the powder at 4°C. Phleomycin is stable for at least 1 year when properly stored.

Product	TDS	MSDS	Qty	Cat. Code	Price
Phleomycin	PDF	PDF	100 mg (20 mg/ml)	ant-ph-1	check
Phleomycin	PDF	PDF	500 mg (20 mg/ml)	ant-ph-5	check
Phleomycin	PDF	PDF	250 mg (powder)	ant-ph-2p	check
Phleomycin	PDF	PDF	500 mg (powder)	ant-ph-5p	check
Phleomycin	PDF	PDF	1 g (powder)	ant-ph-10p	check

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