Our Products

TLR-signaling Inhibitors
MAPK Pathway Inhibitors
NF-κB Pathway Inhibitors
PI3K Pathway Inhibitors
PRR Inhibitors
Inflammasome Inhibitors

Product Lines > Innate Immunity & Inflammation > Signal Transduction Inhibitors

Signal Transduction Inhibitors

InvivoGen offers a selection of known inhibitors of the signaling pathways initiated by pattern recognition receptors (PRRs). These inhibitory molecules intervene in the different steps of PRR activation and signaling cascade, including ligand binding, interaction with adapters, and activation of MAP kinases and NF-κB.

Signal Transduction inhibitors TLR-signaling Inhibitors
BX795
Chloroquine
CLI-095
OxPAPC
Pepinh-MYD
Pepinh-TRIF
Polymyxin B
Rapamycin

MAPK Pathway Inhibitors
PD98059
SB203580
SP600125
U0126

NF-kB Pathway Inhibitors
Bay11-7082
Celastrol

PI3K Pathway Inhibitors
AG490
LY294002
Wortmannin

PRR Activation & Signaling Inhibitors
2-Aminopurine
BX795
Chloroquine
H-89

Inflammasome Inhibitors
Glybenclamide
Z-VAD-FMK

Contents and Storage

TLR-signaling Inhibitors

Product	Description	Endotoxin Level	Working Conc.	TDS	MSDS	Qty	Cat. Code	Price
BX795	TBK1/IKKε inhibitor	<0.125 EU/mg	10 nM - 1 µM	PDF		5 mg	tlrl-bx7	check
Chloroquine	Inhibitor of Endosomal Acidification	<0.125 EU/mg	10 µM	PDF	PDF	250 mg	tlrl-chq	check
CLI-095	TLR4 signaling inhibitor	<0.125 EU/mg	50 nM - 1 µM	PDF	PDF	1 mg	tlrl-cli95	check
OxPAPC	TLR2 and TLR4 inhibitor	<0.125 EU/mg	30 µg/ml	PDF		1 mg	tlrl-oxp1	check
Pepinh-MYD	MyD88 inhibitory peptide	<0.125 EU/mg	50 - 100 µM	PDF		2 mg	tlrl-pimyd	check
Pepinh-TRIF	TRIF inhibitory peptide	<0.125 EU/mg	50 - 100 µM	PDF		2 mg	tlrl-pitrif	check
Polymyxin B	LPS-induced TLR4 activation inhibitor	<0.125 EU/mg	10 µg/ml	PDF	PDF	100 mg	tlrl-pmb	check
Rapamycin	mTOR inhibitor	<0.125 EU/mg	10-100 nM as TLR-signaling inhibitor 10-500 nM as Autophagy Inducer	PDF		5 mg	tlrl-rap	check

MAPK Pathway Inhibitors

Product	Description	Endotoxin Level	Working Conc.	TDS	MSDS	Qty	Cat. Code	Price
PD98059	MAP Kinase Kinase Inhibitor	<0.125 EU/mg	50 - 100µM	PDF	PDF	10 mg	tlrl-pd98	check
SB203580	p38/RK MAP Kinase Inhibitor	<0.125 EU/mg	1 - 20µM	PDF	PDF	5 mg	tlrl-sb20	check
SP600125	JNK inhibitor	<0.125 EU/mg	10-500 µM	PDF	PDF	10 mg	tlrl-sp60	check
U0126	MEK1 and MEK2 Inhibitor	<0.125 EU/mg	10 - 50µM	PDF	PDF	5 mg	tlrl-u0126	check

NF-κB Pathway Inhibitors

Product	Description	Endotoxin Level	Working Conc.	TDS	MSDS	Qty	Cat. Code	Price	Order
Bay11-7082	IκB-α inhibitor	<0.125 EU/mg	1 - 10 µM	PDF	PDF	10 mg	tlrl-b82	check
Celastrol	NF-κB inhibitor	<0.125 EU/mg	2.5 - 10 µM	PDF	PDF	1 mg	ant-cls	check

PI3K Pathway Inhibitors

Product	Description	Endotoxin Level	Working Conc.	TDS	MSDS	Qty	Cat. Code	Price
AG490	JAK2 inhibitor	<0.125 EU/mg	1-100 µM	PDF	PDF	10 mg	tlrl-ag4	check
Wortmannin	PI3K inhibitor	<0.125 EU/mg	0.1-2.5 µM as Signal Transduction Inhibitor 0.1 - 10 μM as Autophagy Inhibitor	PDF	PDF	5 mg	tlrl-wtm	check
LY294002	PI3K Inhibitor	<0.125 EU/mg	50 - 100µM as Signal Transduction Inhibitor 10 - 100 µM as Autophagy Inhibitor	PDF	PDF	5 mg	tlrl-ly29	check

PRR Activation & Signaling Inhibitors

Product	Description	Endotoxin Level	Working Conc.	TDS	MSDS	Qty	Cat. Code	Price
2-AminoPurine	PKR Inhibitor	<0.125 EU/mg	1 - 10 mM	PDF	PDF	250 mg	tlrl-apr	check
BX795	TBK1/IKKε inhibitor	<0.125 EU/mg	10 nM - 1 µM	PDF		5 mg	tlrl-bx7	check
Chloroquine	Inhibitor of Endosomal Acidification	<0.125 EU/mg	10 µM	PDF	PDF	250 mg	tlrl-chq	check
H-89	PKA inhibitor	<0.125 EU/mg	5 - 50 µM	PDF	PDF	5 mg	tlrl-h89	check

Inflammasome Inhibitors

Product	Description	Working Conc.	TDS	MSDS	Qty	Cat. Code	Price	Order
Glybenclamide	Proton pump inhibitor	25 µg/ml	PDF	PDF	1 g	tlrl-gly	check
Z-VAD-FMK	Caspase inhibitor	10 µg/ml or 20 µM	PDF	PDF	1 mg	tlrl-vad	check

Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.

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