Our Products
Signal Transduction Inhibitors
InvivoGen offers a selection of known inhibitors of the signaling pathways initiated by pattern recognition receptors (PRRs). These inhibitory molecules intervene in the different steps of PRR activation and signaling cascade, including ligand binding, interaction with adapters, and activation of MAP kinases and NF-κB.
TLR-signaling Inhibitors
Pepinh-MYD: MyD88 inhibitiry peptide
Pepinh-TRIF: TRIF inhibitory peptide
MAPK Pathway Inhibitors
PD98059: MAP kinase kinase inhibitor
SB203580: p38 MAP kinase inhibitor
SP600125: JNK inhibitor
U0126: MEK1-MEK2 inhibitor
NF-kB Pathway Inhibitors
Bay11-7082: IkB-a inhibitor
Celastrol: NF-kB inhibitor
PI3K Pathway Inhibitors
AG490: JAK2 inhibitor
LY294002: PI3K inhibitor
Wortmannin: PI3K inhibitor
PRR Activation & Signaling Inhibitors
2-Aminopurine: PKR inhibitor
Chloroquine: Endosome acidification inhibitor
CLI-095: TLR4 signaling inhibitor
H-89: PKA inhibitor
Polymyxin B: LPS-induced TLR4 activation inhibitor
TLR-signaling Inhibitors
Pepinh-MYD and pepinh-TRIF are cell-penetrating peptides that interfere with TLR signaling. They contain the BB loop sequences of the TIR domains of MyD88 or TRIF preceeded by a protein transduction sequence derived from antennapedia which enables the peptide to translocate through the cell membrane [1].
Pepinh-MYD blocks MyD88 signaling by inhibiting its homodimerization through binding [2]. Pepinh-TRIF inhibits TRIF signaling by interfering with TLR-TRIF interaction [3].
Pepinh-MYD was shown to significantly block TLR2- and TLR8-induced NF-κB activation in THP1-Blue™ cells while the efficacy of Pepinh-TRIF was confirmed in Ramos-Blue™ cells induced by the TLR3 ligand poly(I:C).
1. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.
2. Loiarro M. et al., 2005. Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-{kappa}B. J. Biol. Chem., 280: 15809-14.
3. Toshchakov vU. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.
| Product | Description | Endotoxin Level | Working Conc. | TDS | Qty | Cat. Code | Price | Order |
|---|---|---|---|---|---|---|---|---|
|
Pepinh-MYD
NEW
|
MyD88 inhibitory peptide | Endotoxin-free | 50 - 100 µM | 2 mg | tlrl-pimyd | check | ||
|
Pepinh-TRIF
NEW
|
TRIF inhibitory peptide | Endotoxin-free | 50 - 100 µM | 2 mg | tlrl-pitrif | check |
MAPK Pathway Inhibitors
| Product | Description | Endotoxin Level | Working Conc. | TDS | MSDS | Qty | Cat. Code | Price | Order |
|---|---|---|---|---|---|---|---|---|---|
|
PD98059
|
MAP Kinase Kinase Inhibitor | Endotoxin-free | 50 - 100µM | 10 mg | tlrl-pd98 | check | |||
|
SB203580
|
p38/RK MAP Kinase Inhibitor | Endotoxin-free | 1 - 20µM | 5 mg | tlrl-sb20 | check | |||
|
SP600125
|
JNK inhibitor | Endotoxin-free | 10-500 µM | 10 mg | tlrl-sp60 | check | |||
|
U0126
|
MEK1 and MEK2 Inhibitor | Endotoxin-free | 10 - 50µM | 5 mg | tlrl-u0126 | check |
NF-κB Pathway Inhibitors
| Product | Description | Endotoxin Level | Working Conc. | TDS | MSDS | Qty | Cat. Code | Price | Order |
|---|---|---|---|---|---|---|---|---|---|
|
Bay11-7082
|
IκB-α inhibitor | Endotoxin-free | 1 - 10 µM | 10 mg | tlrl-b82 | check | |||
|
Celastrol
|
NF-κB inhibitor | Endotoxin-free | 1 mg | ant-cls | check |
PI3K Pathway Inhibitors
| Product | Description | Endotoxin Level | Working Conc. | TDS | MSDS | Qty | Cat. Code | Price | Order |
|---|---|---|---|---|---|---|---|---|---|
|
AG490
|
JAK2 inhibitor | Endotoxin-free | 1-100 µM | 10 mg | tlrl-ag4 | check | |||
|
Wortmannin
|
PI3K inhibitor | Endotoxin-free | 0.1-2.5 µM | 5 mg | tlrl-wtm | check | |||
|
LY294002
|
PI3K Inhibitor | Endotoxin-free | 50 - 100µM | 5 mg | tlrl-ly29 | check |
PRR Activation & Signaling Inhibitors
| Product | Description | Endotoxin Level | Working Conc. | TDS | MSDS | Qty | Cat. Code | Price | Order |
|---|---|---|---|---|---|---|---|---|---|
|
2-AminoPurine
|
PKR Inhibitor | Endotoxin-free | 1 - 10 mM | 250 mg | tlrl-apr | check | |||
|
Chloroquine
|
Inhibitor of Endosomal Acidification | Endotoxin-free | 10 µM | 250 mg | tlrl-chq | check | |||
|
CLI-095
|
TLR4 signaling inhibitor | Endotoxin-free | 50 nM - 1 µM | 1 mg | tlrl-cli95 | check | |||
|
H-89
|
PKA inhibitor | Endotoxin-free | 10-50 µM | 5 mg | tlrl-h89 | check | |||
|
Polymyxin B
|
Inhibitor of LPS-induced TLR4 activation | Endotoxin-free | 10 µg/ml | 100 mg | tlrl-pmb | check |


Inhibitory activities of Pepinh-MYD and Pepinh-TRIF.