Product Lines > Innate Immunity & Inflammation > Signal Transduction Inhibitors

Signal Transduction Inhibitors

InvivoGen offers a selection of known inhibitors of the signaling pathways initiated by pattern recognition receptors (PRRs). These inhibitory molecules intervene in the different steps of PRR activation and signaling cascade, including ligand binding, interaction with adapters, and activation of MAP kinases and NF-κB.

Signal   Transduction inhibitorsTLR-signaling Inhibitors
BX795
Chloroquine
CLI-095
OxPAPC
Pepinh-MYD
Pepinh-TRIF
Polymyxin B
Rapamycin

MAPK Pathway Inhibitors
PD98059
SB203580
SP600125
U0126

NF-kB Pathway Inhibitors
Bay11-7082
Celastrol

PI3K Pathway Inhibitors
AG490
LY294002
Wortmannin

PRR Activation & Signaling Inhibitors
2-Aminopurine
BX795
Chloroquine
H-89

Inflammasome Inhibitors
Glybenclamide
Z-VAD-FMK

Contents and Storage

TLR-signaling Inhibitors


ProductDescriptionEndotoxin LevelWorking Conc.TDS MSDSQtyCat.
Code
Price Order 
BX795
TBK1/IKKε inhibitor<0.125 EU/mg10 nM - 1 µMPDF 5 mg tlrl-bx7check cart
Chloroquine
Inhibitor of Endosomal Acidification<0.125 EU/mg10 µMPDFPDF250 mg tlrl-chqcheck cart
CLI-095
TLR4 signaling inhibitor<0.125 EU/mg50 nM - 1 µMPDFPDF1 mg tlrl-cli95check cart
OxPAPC
TLR2 and TLR4 inhibitor<0.125 EU/mg30 µg/mlPDF 1 mg tlrl-oxp1check cart
Pepinh-MYD
MyD88 inhibitory peptide<0.125 EU/mg50 - 100 µMPDF 2 mg tlrl-pimydcheck cart
Pepinh-TRIF
TRIF inhibitory peptide<0.125 EU/mg50 - 100 µMPDF 2 mg tlrl-pitrifcheck cart
Polymyxin B
LPS-induced TLR4 activation inhibitor<0.125 EU/mg10 µg/mlPDFPDF100 mg tlrl-pmbcheck cart
Rapamycin
mTOR inhibitor<0.125 EU/mg10-100 nM as TLR-signaling inhibitor
10-500 nM as Autophagy Inducer
PDF 5 mg tlrl-rapcheck cart

MAPK Pathway Inhibitors


ProductDescriptionEndotoxin LevelWorking Conc.TDS MSDSQtyCat.
Code
Price Order 
PD98059
MAP Kinase Kinase Inhibitor<0.125 EU/mg50 - 100µMPDFPDF10 mg tlrl-pd98check cart
SB203580
p38/RK MAP Kinase Inhibitor<0.125 EU/mg1 - 20µMPDFPDF5 mg tlrl-sb20check cart
SP600125
JNK inhibitor<0.125 EU/mg10-500 µMPDFPDF10 mg tlrl-sp60check cart
U0126
MEK1 and MEK2 Inhibitor<0.125 EU/mg10 - 50µMPDFPDF5 mg tlrl-u0126check cart


NF-κB Pathway Inhibitors


ProductDescriptionEndotoxin LevelWorking Conc.TDS MSDSQtyCat.
Code
Price Order 
Bay11-7082
IκB-α inhibitor<0.125 EU/mg1 - 10 µMPDFPDF10 mg tlrl-b82check cart
Celastrol
NF-κB inhibitor<0.125 EU/mg2.5 - 10 µMPDFPDF1 mg ant-clscheck cart


PI3K Pathway Inhibitors


ProductDescriptionEndotoxin LevelWorking Conc.TDS MSDSQtyCat.
Code
Price Order 
AG490
JAK2 inhibitor<0.125 EU/mg1-100 µMPDFPDF10 mg tlrl-ag4check cart
Wortmannin
PI3K inhibitor<0.125 EU/mg0.1-2.5 µM as Signal Transduction Inhibitor
0.1 - 10 μM as Autophagy Inhibitor
PDFPDF5 mg tlrl-wtmcheck cart
LY294002
PI3K Inhibitor<0.125 EU/mg50 - 100µM as Signal Transduction Inhibitor
10 - 100 µM as Autophagy Inhibitor
PDFPDF5 mg tlrl-ly29check cart


PRR Activation & Signaling Inhibitors


ProductDescriptionEndotoxin LevelWorking Conc.TDS MSDSQtyCat.
Code
Price Order 
2-AminoPurine
PKR Inhibitor<0.125 EU/mg1 - 10 mMPDFPDF250 mg tlrl-aprcheck cart
BX795
TBK1/IKKε inhibitor<0.125 EU/mg10 nM - 1 µMPDF 5 mg tlrl-bx7check cart
Chloroquine
Inhibitor of Endosomal Acidification<0.125 EU/mg10 µMPDFPDF250 mg tlrl-chqcheck cart
H-89
PKA inhibitor<0.125 EU/mg5 - 50 µMPDFPDF5 mg tlrl-h89check cart


Inflammasome Inhibitors


ProductDescriptionWorking Conc.TDS MSDSQtyCat.
Code
Price Order 
Glybenclamide
Proton pump inhibitor25 µg/mlPDFPDF1 g tlrl-glycheck cart
Z-VAD-FMK
Caspase inhibitor10 µg/ml or 20 µMPDFPDF1 mg tlrl-vadcheck cart


Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.

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