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Custom-made Promoters

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Create Your Own Composite Promoter

You can create your own composite promoter by combining the enhancer, core promoter and 5‘UTR of your choice. We will assemble your composite promoter in one of our ready-made pDRIVE plasmids.

Features and Benefits

Customize Your Promoter
Choose the enhancer, the core promoter and 5’UTR from InvivoGen’s lists, and we will generate the composite promoter of your choice.

• Enhancer
InvivoGen provides a choice of ubiquitous or specific enhancers.
Choose any enhancer from the list below:

Enhancer	Name	Origin	Size	Specificity	References
AFP	Alpha-Fetoprotein	Human	1854 bp	AFP-positive cells	Cao G., 2001, Eur J Cancer. 37(1):140-7
CEA	Carcinoembryonic antigen	Human	1434 bp	CEA-positive cells	Richards CA.,1995, Hum Gene Ther. 6:881-893
CMV	Cytomegalovirus	Viral	405 bp	Ubiquitous	Liu BH., 2004, Gene Ther. 11(1):52-60
P2	Adipocyte P2	Mouse	511 bp	Adipose tissues	Ross SR., 1990, PNAS 1990 Dec;87(24):9590-4
PSA	Prostate specific antigen	Human	1591 bp	PSA-positive cells only	Lee SE., 2000, Anticancer Res. 20(1A):417-22
SV40	Simian virus	Viral	235 bp	Ubiquitous	Moreau P., 1981, Nucleic Acids Res. 9(22):6047-68
Tie2	Angiopoietin receptor	Mouse	282 bp	Vascular ECs	Schlaeger TM., 1997, PNAS. 94(7):3058-63
Tyr	Tyrosinase	Mouse	201 bp	Melanocytes & Melanoma	Park BJ., 1999, Hum Gene Ther 10(6):889-98

• Core promoter
You can choose the core promoter from the list of ubiquitous, tissue-specific or tumor-specific native promoters.

• 5’UTR
The 5’ untranslated region can be chosen from the list below:

5‘UTR	Name	Origin	Size	Activity	References
AdTp	Adenotripartite	Viral	135 bp	Enhances translation	Sheay W., 1993, Biotechniques 15(5): 856-62
EF-1α	Elongation factor 1 alpha	Chimp.	988 bp	Increases mRNA translation	Kim SY., 2002, J Biotechnol. 14;93(2): 183-7
		Mouse	1014 bp
eIF4g	Eukaryotic initiation factor 4g	Human	314 bp	Contains a putative IRES	Han B., 2002, Mol Cell Biol 22(21): 7372-84
HSP70	Heat shock protein 70	Human	195 bp	Increases mRNA translation	Vivinus S., 2001, Eur J Biochem. 268(7): 1908-17
NRF	NF-κ B repressing factor	Mouse	880 bp	Acts as a potent IRES	Oumard A., 2000, Mol Cell Biol. 20(8): 2755-9
HTLV RU5‘	Human T-cell leukemia virus	Human	267 bp	Increases mRNA translation	Takebe Y., 1988, Mol. Cell Biol. 8(1): 466-472

Choose Your Selection
Custom-made pDRIVE carry the Zeocin™ resistance gene for selection and amplification in E. coli. We can replace the bacterial selection cassette with a mammalian selection cassette of your choice derived from a pSELECT plasmid.

Contents and Storage
Each custom-made pDRIVE plasmid is provided as 20 µg lyophilized DNA. Product is shipped at room temperature. Store at -20°C. Plasmids are stable up to one year when properly stored.

Product	Quantity	Catalog Code	Price & Order
pDRIVE-custom	20 µg	p-custom	contact us

Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.

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