NF-κB inhibitor

Celastrol, a quinone methide triterpene isolated from the Chinese medicinal plant Tripterygium wilfordii, is known for its antitumor and anti-inflammatory properties but its mode of action and spectrum of cellular targets are poorly understood. Celastrol was recently found to be a potent inhibitor of the heat-shock protein Hsp90 inducing the disruption of protein-protein interactions of Hsp90 and its co-chaperones [1,2]. Furthermore, it was shown to act as an effective inhibitor of the transcription factor NF-κB potentiating the apoptosis induced by TNF-α and chemotherapeutic agents and inhibiting invasion [3].


Working concentration: 300 nM-10 μM
Purity: ≥95%
Endotoxin levels: CAS number: 34157-83-0
Molecular weight: 450.6
Solubility: 10 mg/ml in DMSO


•  1 mg


1. Zhang T. et al., 2008. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther., 7: 162-170.
2. Hieronymus H. et al., 2006. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell, 10(4): 321-330.
3. Sethi G. et al., 2007. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood, 109: 2727-2735.



Description NF-κB inhibitor
Cat. Codeant-cls
Unit Size1 mg
Price For price or distributor address,
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