STING agonist negative control

Cyclic di-uridine monophosphate (c-di-UMP) is a synthetic cyclic dinucleotide containing a pyrimidine base.

Unlike the purine-containing cyclic dinucleotides (c-di-AMP, c-di-GMP and c-di-IMP), c-di-UMP is not predicted to bind strongly to STING [1]. The smaller size of the pyrimidine base is expected to prevent the formation of stacking interactions that are crtitical for proper binding to STING. Indeed, STING-expressing cells, such as THP1-Blue™ ISG cells, do not respond to c-di-UMP, even at high concentrations.


Description: STING agonist negative control
Synonym: Cyclic di-uridine monophosphate, c-di-UMP sodium salt
CAS number: 73120-97-5
Formula: C18H20N4O16P2 .2Na
Molecular weight: 656.3
Purity: ≥ 95% by LC/MS
Solubility: 50 mg/ml in water

Quality control:
- The inability of c-di-UMP to induce the STING/TBK1/IRF3 pathway has been confirmed in THP1-Blue™ ISG cells.
- The absence of endotoxins and other bacterial contaminants has been confirmed using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.



- 1 mg lyophilized c-di-UMP
- 1.5 ml endotoxin-free water

Product is shipped at room temperature and should be stored at -20°C. Product is sterile filtered prior to lyophilization.


1. Yin Q. et al., 2012. Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 46(6):735-45.


Recent articles using InvivoGen c-di-UMP



Description STING agonist negative control
Cat. Codetlrl-nacdu
Unit Size1 mg
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