c-di-GMP Control

STING agonist negative control

c-di-GMP Control, also known as 5'-pGpG, is a linear dinucleotide analog that can be obtained after hydrolysis of cyclic diguanylate monophosphate (c-di-GMP) by phosphodiesterases [1]. c-di-GMP is a cyclic dinucleotide (CDN) produced in bacteria in which it functions as a second messenger. c-di-GMP is involved in complex biological processes, such as biofilm formation, virulence and photosynthesis.

CDNs including c-di-GMP bind the cytosolic DNA sensor STING (stimulator of interferon genes) and induce the production of type I interferons (IFNs). Due to its linear conformation, 5'-pGpG is intended to serve as a negative control for c-di-GMP in type I IFN induction assays. The importance of dinucleotide conformation has been well established in bacteria, where RNA regulatory riboswitches are able to discriminate between biologically active CDNs and their corresponding linear dinucleotides [2-4].



Description: c-di-GMP negative control
Synonym: 5'-pGpG sodium salt
CAS number: 33008-99-0
Formula: C20H23N10O15P2 .3Na
Molecular weight: 774.38
Purity: ≥ 95% by LC/MS
Solubility: 50 mg/ml in water

Quality control:
The inability of c-di-GMP Control to induce type I interferon (IFN) has been confirmed in THP1-Blue™ ISG cells.
- The absence of endotoxins and other bacterial contaminants has been confirmed using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.


- 1 mg lyophilized c-di-GMP Control
- 1.5 ml endotoxin-free water

Product is shipped at room temperature and should be stored at -20 °C. Product is sterile filtered prior to lyophilization.


1. Römling U. et al., 2013. Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger. Microbiol Mol Biol Rev. 77(1): 1–52.
2. Ren A. et al., 2015. Structural Basis for Molecular Discrimination by a 3',3'-cGAMP Sensing Riboswitch. Cell Rep. 11(1):1-12.
3. Gao J. et al., 2015. Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP. Cell Res. 25(5):539-50.
4. Witte CE. et al., 2013. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. MBio. 4(3):e00282-13.


c-di-GMP Control

Description STING agonist negative control
Cat. Codetlrl-napgpg
Unit Size1 mg
Price For price or distributor address,
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