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RNA Interference

InvivoGen provides a plasmid-based system developed to knockdown efficiently the expression of mammalian genes:
- Selection of Candidate siRNA/shRNA and Design of Hairpin Insert: siRNA Wizard Software
- Cloning of siRNA/shRNA Insert : psiRNA-h7SK, psiRNA-DUO, psiRNA Tools
- siRNA/shRNA Prevalidation: psiTEST

Interferon Response Detection

The immunostimulatory “side effects” of siRNAs must be taken into account when inducing RNAi. InvivoGen is introducing a set of primers designed to detect an IFN-response by real-time quantitative PCR.
Furthermore, the use of pCpGfree-siRNA, a CpG-free plasmid designed for the production of shRNAs that does not activate TLR9, may further limit the induction of an siRNA-induced immune response.

psiRNA Vectors

Ready-made psiRNA: a family of plasmids expressing siRNAs functionality described in literature or validated in house.
Precomplexed psiRNAs: a selection of ready-made psiRNAs already complexed with a transfection reagent.
Custom-made psiRNA: a complete siRNA service to help you speed-up your gene silencing experiments.

Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.

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