Our Products
Toll-Like Receptors
InvivoGen offers a large set of tools to study Toll-Like Receptors (TLRs) pathways: TLR and related genes, TLR expressing cell lines, TLR Detection products, antibodies against TLR, TLR inhibitors, a large choice of TLR ligands and antagonist.
Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganisms. These evolutionarily conserved receptors, homologues of the Drosophila Toll gene, recognize highly conserved structural motifs only expressed by microbial pathogens, called pathogen-associated microbial patterns (PAMPs). [Learn more]
InvivoGen offers the largest collection of human and mouse genes involved in the TLR pathways.
The entire open reading frames (ORFs) of these genes are provided in an expression plasmid and are fully sequenced. The genes are available native, tagged or modified to act as dominant negative mutants.
InvivoGen provides an expanding collection of TLR expressing and reporter cells lines. These cells enable efficient monitoring of TLR activity using ELISA analysis such as IL-8 titration or reporter-based systems that monitor the activation of NF-κB.
InvivoGen offers a comprehensive set of tools designed for the detection of Toll-like receptors. These tools include primers to detect the expression of the TLRs at the mRNA or protein level, fusions between the TLRs and a fluorescent protein to study their localization and a family of inducible plasmids to monitor TLR activation.
- TLR antibodies include a selection of IgA chimeric monoclonal antibodies, IgG monoclonal antibodies and IgG polyclonal antibodies. Most of these antibodies can be used in neutralization experiments, but also for other applications such as flow cytometry, immunochemistry and Western blotting.
- Anti-HA antibody is provided to detect the expression of TLR proteins fused to the HA tag by Western blot or immunoprecipitation.
InvivoGen offers the largest choice of ligands known to activate specific TLRs, that can serve as controls in genetic and pharmaceutical studies on TLRs. The ligands are available individually or in kits.
InvivoGen provides a number of tools that should prove useful to help elucidate the molecular mechanisms involved in TLR signaling. These tools include dominant negative TLRs, short hairpin RNAs (shRNAs) that silence TLR and adaptor genes and inhibitors of TLR signaling.
TLR Ligand Detection
Endotoxin Detection: InvivoGen provides the HEK-Blue™ LPS Detection Kit, a simple, rapid and reliable system to detect the presence of lipopolysaccharides in your samples.
TLR Ligand Screening: InvivoGen has developed an innovative method to determine whether a compound is recognized by TLRs and acts either as an agonist or antagonist.