Bix-01294
Reprogramming Enhancer
Bix-01294 is an inhibitor of the G9a histone methyltransferase, a key regulator of DNA methylation and transcriptional silencing in pluripotent cells [1]. Bix-01294 is believed to facilitate the reactivation of pluripotency genes and induce passive demethylation, thus promoting reprogramming. Indeed, Bix-01294 was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells by approximately 8-fold [2].
Specifications
Working concentration: 1 µM
CAS number: 935693-62-2
Purity: >98% (HPLC)
Molecular weight: 600.02
Solubility: Water (20 mg/ml)
Contents
• 2 mg Bix-01294
Ref.
1. Epsztejn-Litman S. et al., 2008. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol. 15(11):1176-83.
2. Shi Y et al., 2008. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2(6):525-8.
ORDERING
Bix-01294
| Description | G9a histone methyltransferase inhibitor |
|---|---|
| Cat. Code | inh-bix |
| Unit Size | 2 mg |
| Price | For price or distributor address, please select your country |