Bix-01294

Reprogramming Enhancer

Bix-01294 is an inhibitor of the G9a histone methyltransferase, a key regulator of DNA methylation and transcriptional silencing in pluripotent cells [1]. Bix-01294 is believed to facilitate the reactivation of pluripotency genes and induce passive demethylation, thus promoting reprogramming. Indeed, Bix-01294 was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells by approximately 8-fold [2].

Specifications

Working concentration: 1 µM
CAS number:
935693-62-2
Purity:
>98% (HPLC)
Molecular weight:
600.02
Solubility:
Water (20 mg/ml)

Contents

• 2 mg Bix-01294

Ref.

1. Epsztejn-Litman S. et al., 2008. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol. 15(11):1176-83.
2. Shi Y et al., 2008. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2(6):525-8.

ORDERING

Bix-01294

Description G9a histone methyltransferase inhibitor
Cat. Code inh-bix
Unit Size 2 mg
Price For price or distributor address,
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