Autophagy Inhibitors

Inhibitors that block or induce autophagy
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Autophagy is an orchestrated homeostatic process to eliminate unwanted proteins and damaged organelles. The autophagic process is also used to remove intracellular microbial pathogens.
Several signaling pathways sense different types of cell stress, ranging from nutrient deprivation to microbial invasion, and converge to regulate autophagy at multiple stages of the process.

The primary step in inducing autophagy involves membrane nucleation, controlled by ULK complex and Beclin1. Inhibitors of positive regulators of of the ULK complex and Beclin1 have been demonstrated to block autophagy. These include inhibitors to the MAP kinases, JNK1, ERK and p38. The induction of Atg protein and LC3 proteins is required for vesicle expansion and formation. Inhibitors of the class III PI3 kinases can block autophagy. In a later step of the autophagic process, inhibitors that inhibit lysosome acidification essentially block the formation of autophagosome and autophagic degradation.

InvivoGen provides inhibitors that target molecules involved in these pathways that can impact autophagy and can be used to study autophagy in cells.

Inhibitors of Beclin1

SP600125 MAP Kinase Inhibitor - Autophagy Inhibitor - JNK inhibitor 10 mg
U0126 MAPK Kinase Inhibitor - Autophagy Inhibitor - MEK1 and MEK2 Inhibitor 5 mg

Inhibitors of autophagosome / autophagolysosome formation

3-Methyladenine PI3K inhibitor - Autophagy Inhibitor 50 mg
Bafilomycin A1 Endosomal Acidification Inhibitor - Autophagy Inhibitor 10 µg
Chloroquine Endosomal Acidification Inhibitor - TLR signaling inhibitor - Autophagy Inhibitor 250 mg
LY294002 PI3K inhibitor - Autophagy Inhibitor 5 mg
SB202190 MAP Kinase Inhibitor - p38/RK MAP Kinase Inhibitor - Autophagy inducer 5 mg
SB203580 MAP Kinase Inhibitor - p38 MAP Kinase Inhibitor - Autophagy inducer 5 mg
Wortmannin PI3K inhibitor - Autophagy Inhibitor 5 mg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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