Autophagy Inhibitors

Inhibitors that block or induce autophagy
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Autophagy is an orchestrated homeostatic process to eliminate unwanted proteins and damaged organelles. The autophagic process is also used to remove intracellular microbial pathogens.
Several signaling pathways sense different types of cell stress, ranging from nutrient deprivation to microbial invasion, and converge to regulate autophagy at multiple stages of the process.

The primary step in inducing autophagy involves membrane nucleation, controlled by ULK complex and Beclin1. Inhibitors of positive regulators of of the ULK complex and Beclin1 have been demonstrated to block autophagy. These include inhibitors to the MAP kinases, JNK1, ERK and p38. The induction of Atg protein and LC3 proteins is required for vesicle expansion and formation. Inhibitors of the class III PI3 kinases can block autophagy. In a later step of the autophagic process, inhibitors that inhibit lysosome acidification essentially block the formation of autophagosome and autophagic degradation.

InvivoGen provides inhibitors that target molecules involved in these pathways that can impact autophagy and can be used to study autophagy in cells.

Inhibitors of Beclin1

SP600125MAP Kinase Inhibitor - Autophagy Inhibitor - JNK inhibitor10 mg
U0126MAPK Kinase Inhibitor - Autophagy Inhibitor - MEK1 and MEK2 Inhibitor5 mg

Inhibitors of autophagosome / autophagolysosome formation

3-MethyladeninePI3K inhibitor - Autophagy Inhibitor50 mg
Bafilomycin A1Endosomal Acidification Inhibitor - Autophagy Inhibitor10 µg
ChloroquineEndosomal Acidification Inhibitor - TLR signaling inhibitor - Autophagy Inhibitor250 mg
LY294002PI3K inhibitor - Autophagy Inhibitor5 mg
SB202190MAP Kinase Inhibitor - p38/RK MAP Kinase Inhibitor - Autophagy inducer5 mg
SB203580MAP Kinase Inhibitor - p38 MAP Kinase Inhibitor - Autophagy inducer5 mg
SC79 NEWAkt activator; autophagy inhibitor10 mg
WortmanninPI3K inhibitor - Autophagy Inhibitor5 mg
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Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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