Anti-TLR5 Antibodies

InvivoGen provides a collection of monoclonal and polyclonal antibodies targeting human and mouse Toll-like receptor 5 (TLR5) for neutralization. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88 [1, 2]. TLR5 can generate a proinflammatory signal as a homodimer suggesting that it might be the only TLR participating in flagellin recognition [2]. However, TLR5 may require the presence of a co-receptor or adaptor molecule for efficient ligand recognition and/or signaling [3].

1. Gewirtz AT. et al., 2001. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol, 167(4):1882-5.
2. Hayashi F. et al., 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature, 410(6832):1099-103.
3. Tallant T. et al., 2004. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol. 4(1):33.

Anti-hTLR5-IgAHuman TLR5 Detection and Neutralizing antibody - Monoclonal Human IgA2 (Q2G4)100 µg
Anti-mTLR5-IgGMouse TLR5 Neutralizing antibody - Monoclonal Rat IgG2a (Q23D11)100 µg
PAb-hTLR5Human TLR5 Neutralizing antibody - Polyclonal Rat IgG200 µg
Anti-FlagellinS. typhimurium flagellin FliC Detection antibody - Mouse monoclonal IgG1 (X5A12)100 µg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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