InvivoGen provides monoclonal antibodies targeting human IL-18 for neutralization and detection.

Interleukin 18 (IL-18; formerly called interferon-γ inducing factor) is a pro-inflammatory cytokine that causes a wide variety of biological effects associated with infection, inflammation and autoimmune processes [1, 2]. More specifically, IL-18 induces IFN-γ production and contributes to T-helper 1 (Th1) cell polarization. IL-18 is produced by macrophages and other cells, as a proprotein which is proteolytically processed to its active form by caspase 1, an enzyme that is activated within the inflammasome multiprotein complex. IL-18 binds to an heterodimeric receptor consisting of IL-18R and IL-18 receptor accessory protein (IL-18RAP). Upon binding, IL-18 activates NF-κB and AP-1 via signaling pathways that involve IRAK and TRAF-6 [3, 4].

  1. Arend W. et al., 2008. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 223:20-38.
  2. Dinarello CA. et al., 1998. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol. 63(6):658-64.
  3. Gracie JA. et al., 2003. Interleukin-18. J Leukoc Biol.3(2):213-24.
  4. Kojima H. et al., 1998. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. BBRC 244(1):183-6.

Anti-hIL-18-IgG NEWNeutralizing hIgG1 monoclonal antibody to human interleukin 18 (H7WM210)3 x 100 µg
Anti-hIL-18-IgANeutralizing hIgA2 monoclonal antibody to human interleukin 18 (H7WM210)3 x 100 µg
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
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