Neutralizing human IgM monoclonal antibody against human TNF-α

Anti-hTNF-α-hIgM is a neutralizing monoclonal antibody featuring the constant region of the human IgM isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgM was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein L. The neutralizing activity of this human IgM antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.


Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgM


100 µg purified anti-hTNFα-hIgM antibody, provided azide-free and lyophilized



Cat. Codehtnfa-mab5
Unit Size100 µg
Price For price or distributor address,
please select your country
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "".