AMPK Activator (mTOR Inhibitor)

A-769662 is a potent and reversible activator of AMPK (AMP-activated protein kinase), an energy sensing serine/threonine protein kinase important in cellular metabolism [1].

Through the activation of AMPK, A-769662 inhibits mammalian target of rapamycin (mTOR), an enzyme in the PI3K/AKT/mTOR intracellular signalling pathway that plays a central role in cell proliferation, growth, and survival [2].

Studies demonstrate that A-769662 inhibits cell proliferation of various cell types [3, 4]. In addition to its role in cell metabolism and proliferation, A-769662 is also considered as an anti-inflammatory agent as it reduces the activation of JNK, a member of the mitogen-activated protein kinase (MAPK) family that plays an essential role in inflammatory responses [5, 6].


Working Concentration: 100 -300 μM
CAS number:
Synonym: 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Formula: C20H12N2O3S
Molecular weight: 360.39
Solubility: DMSO (30 mg/ml)
Purity: >98% (UHPLC)
Quality control:
The absence of bacterial contamination (e.g. endotoxins and peptidoglycans) is controlled using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.


10 mg A-769662

A-769662 is provided as a solid and shipped at room temperature.
Store at -20°C. Solid product is stable at least 1 year at -20°C.


  1. Göransson O. et al., 2007. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 282(45):32549-60.
  2. van der Heijden M. & Bernards R., 2010. Inhibition of the PI3K pathway: Hope we can believe in? Clin Cancer Res. 16(12):3094-9.
  3. de Meester C. et al., 2013. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.
  4. Peyton K. et al., 2012. Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells. J Pharmacol Exp Ther. 342(3):827-34
  5. Dandapani M. & Hardie DG., 2013. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells? Biochem Soc Trans. 41(2): 687–693.
  6. Galic S. et al., 2011. Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J. Clin. Invest.121(12):4903–4915


Recent articles using InvivoGen A-769662



Description AMPK Activator (mTOR Inhibitor)
Cat. Codeinh-a769
Unit Size10 mg
Price For price or distributor address,
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