293/hTLR1-HA cells were obtained by stable transfection of HEK293 cells with the pUNO-hTLR1-HA plasmid which expresses the human TLR1 gene fused at the 3'end to the influenza hemaglutinine (HA).

The control cell line for 293/hTLR1-HA cells is 293/null.


Antibiotic resistance: Blasticidin

Growth medium: DMEM, 4.5 g/l glucose, 2-4 mM L-glutamine, 10% (v/v) fetal bovine serum, 50 U/ml penicillin, 50 μg/ml streptomycin, 100 μg/ml Normocin™

Guaranteed mycoplasma-free

Shipped on dry ice


1 vial containing 3-7 x 106 cells

100 μl Blasticidin (10 mg/ml)

1 ml Normocin™ (50 mg/ml)


TLR1 is predominently expressed in the spleen and peripheral blood cells. No direct ligands have been identified so far for TLR1, and its function remains unclear. TLR1 seems to act as a coreceptor for TLR2. TLR1 and TLR2 form heterodimeric complexes on the cell surface and in the cytosol [1]. TLR1 and TLR2 were shown to cooperate in recognizing Borrelia burgdorferi outer-surface protein A lipoprotein OspA [2]. They also interact to recognize the 19-kD mycobacterial lipopeptide and several synthetic triacylated lipopeptides [3], but not diacylated lipopeptides. This suggests that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration [4].

1. Sandor F. et al., 2003. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003 Sep 15;162(6):1099-110.
2. Alexopoulou L. et al., 2002. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 8(8):878-84.
3. Takeuchi O. et al., 2002. Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol, 169(1):10-4
4. Takeuchi O. et al., 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol, 13(7):933-40



Description HEK 293 cells stably transfected with the HA-tagged human TLR1 gene
Cat. Code293-htlr1ha
Unit Size3-7 x 10e6 cells
Price For price or distributor address,
please select your country
Disclaimer: Our products are provided for research purpose only. Commercial applications may require licensing from third parties.
Note that the sequence of available ORFs provided by InvivoGen can differ from a given reference Genbank record due to genetic variations and/or alternative splicing. Customers should verify that the version of a gene sold by InvivoGen is suitable for the customer needs.
Copyrights © 2011-2016 InvivoGen. All Rights Reserved. Reproduction of any materials from this site is strictly forbidden without permission for commercial use. Nonprofit use for non-commercial research and educational purposes is permitted, citation should include the URL "www.invivogen.com".