GA analog for coupling of NH2-containing molecules

17-NHS-ALA-GA is an NHS (N-hydroxysuccinimide) activated geldanamycin analog designed for easy coupling of NH2-containing molecules. NHS coupling forms a chemically stable amide bond with ligands containing primary amino groups such as small proteins and peptides. Thus, 17-NHS-ALA-GA can be used for conjugation of GA to a monoclonal antibody similarly to 17-GMB-APAGA[1,2]. It can also be used to perform affinity chromatography to purify GA binding proteins such as Hsp90.


Formula: C44H84N4O12

Molecular weight: 841

Solubility: DMSO (10 mg/ml)


- 1 mg


1. Mandler R. et al., 2002. Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates. Bioconjug Chem. 13(4):786-91.
2. Mandler R et al. 2000. Immunoconjugates of Geldanamycin and Anti-HER2 Monoclonal Antibodies.



Cat. Codeant-nhgl-1
Unit Size1 mg
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